COUPLED 2025

Separable hierarchical priors applied to analysis of synergies in human locomotion

  • Calvetti, Daniela (Case Western Reserve University)
  • Arnold, Andrea (Worcester Polytechnic Institute)
  • Davico, Giorgio (University of Bologna)
  • Hoover, Alexander (Cleveland State University)
  • Somersalo, Erkki (Case Western Reserve University)

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It has been hypothesized that the during a motion task the central nervous system controls the skeletal muscles by partitioning them into synergetic groups, hence effectively reducing the dimensionality of the control problem. The identification of muscle groups that are co-activated remains an open problem: its solution could have important implications in the design of training or rehabilitation protocols. In this article we combine Bayesian inverse problem techniques and data science algorithms to identify muscle synergies in human motion from the motion tracker time series of positions of fiducial markers on the body during the task. The inverse problem of estimating of the muscle activation patterns from the motion tracking data is cast in the Bayesian framework, and the posterior distribution of muscle activations is explored using Myobolica, a Gibbs-sampler based Markov chain Monte Carlo sampler. A low-rank approximation of the muscle activation patterns is then obtained via a sparsity pr